Characterization of the Phosphodiesterase Subtypes That Regulate Mouse Atrial Myocyte Electrophysiology
نویسنده
چکیده
....................................................................................................................... x LIST OF ABBREVIATIONS USED ................................................................................ xi ACKNOWLEGMENTS .................................................................................................. xiv CHAPTER 1: INTRODUCTION ....................................................................................... 1 1.1 Cyclic Nucleotides ....................................................................................................... 1 1.2 Regulation of Cardiac Function by Cyclic Nucleotides ............................................... 4 1.2.1 Cardiac Excitation-Contraction Coupling .............................................................. 4 1.2.2 Pathways Regulating cAMP in the Heart ............................................................... 5 1.2.2.1 Degradation of Intracellular cAMP ................................................................. 6 1.2.3 Pathways Regulating cGMP in the Heart ............................................................... 7 1.2.3.1 Nitric Oxide Signaling in the Heart ................................................................. 7 1.2.3.2 Natriuretic Peptide Signaling in the Heart ....................................................... 8 1.2.3.3 cGMP Signaling .............................................................................................. 8 1.3 Cyclic Nucleotide Phosphodiesterases ......................................................................... 9 1.3.1 General PDE Structure ......................................................................................... 13 1.3.1.1 Regulatory Domain ........................................................................................ 13 1.3.1.2 The Catalytic Domain .................................................................................... 14 1.3.1.3 Cyclic Nucleotide Recognition ...................................................................... 15 1.3.2 Pharmacology ....................................................................................................... 16
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